Yes!
Creatine is the most widely researched supplement on the market!
In a 21 consecutive month study on long-term creatine supplementation, creatine was found to produce no ill health effects. There is no need to cycle off of creatine because your body will not develop a creatine tolerance, such as it does with caffeine.
Aside from supplementation, creatine is produced naturally in the body by the liver, kidneys, and pancreas at a rate of about 1-2 grams per day and can also be obtained by consuming red meat.